The strong word and stance issue only from a strict will, a will that dares the error of reading all of reality as a text, and all prior texts as openings for its own totalizing and unique interpretations. Strong poets present themselves as looking for truth in the world, searching in reality and in tradition, but such a stance, as Nietzsche said, remains under the mastery of desire, of instinctual drives. So, in effect, the strong poet wants pleasure and not (...) truth; he wants what Nietzsche named as "the belief in truth and the pleasurable effects of this belief." No strong poet can admit that Nietzsche was accurate in this insight, and no critic need fear that any strong poet will accept and so be hurt by demystification. The concern of this book, as of my earlier studies in poetic misprision, is only with strong poets, which in this series of chapters is exemplified by the major sequence of High Romantic British and American poets: Blake, Wordsworth, Shelley, Keats, Tennyson, Browning, Yeats, Emerson, Whitman, and Stevens, but also throughout by two of the strongest poets in the European Romantic tradition: Nietzsche and Freud. By "poet" I therefore do not mean only verse-writer, as the instance of Emerson also should make clear. Harold Bloom is DeVane Professor of the Humanities at Yale University. This article is the first chapter of his new book, Poetry and Repression, to be published by the Yale University Press. The book completes a tetralogy, of which the earlier volumes are The Anxiety of Influence, A Map of Misreading, and Kabbalah and Criticism. See also: "Formalism, Savagery, and Care; or, The Function of Criticism Once Again" by Jerome J. McGann in Vol. 2, No. 3; "The Poet as Elaborator: Analytical Psychology as a Critical Paradigm" by David D. Cooper in Vol. 6, No. 1. (shrink)

Bloom leads readers through the labyrinthine paths which link the writers and critics who have informed and inspired him for so many years.

Representing species-specific proteins and protein complexes in ontologies that are both human and machine-readable facilitates the retrieval, analysis, and interpretation of genome-scale data sets. Although existing protin-centric informatics resources provide the biomedical research community with well-curated compendia of protein sequence and structure, these resources lack formal ontological representations of the relationships among the proteins themselves. The Protein Ontology (PRO) Consortium is filling this informatics resource gap by developing ontological representations and relationships among proteins and their variants and modified forms. Because (...) proteins are often functional only as members of stable protein complexes, the PRO Consortium, in collaboration with existing protein and pathway databases, has launched a new initiative to implement logical and consistent representation of protein complexes. We describe here how the PRO Consortium is meeting the challenge of representing species-specific protein complexes, how protein complex representation in PRO supports annotation of protein complexes and comparative biology, and how PRO is being integrated into existing community bioinformatics resources. The PRO resource is accessible at http://pir.georgetown.edu/pro/. (shrink)

A collection of critical essays on the works of Friedrich Nietzsche, arranged in chronological order of publication.

The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to enhance accessibility to results of protein (...) research. PRO (http://pir.georgetown.edu/pro) is part of the Open Biomedical Ontologies (OBO) Foundry. (shrink)

The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the building, curation, usage and dissemination of PRO. PRO provides a framework (...) for the formal representation of protein classes and protein forms in the OBO Foundry. It is designed to enable data retrieval and integration and machine reasoning at the molecular level of proteins, thereby facilitating cross-species comparisons, pathway analysis, disease modeling and the generation of new hypotheses. (shrink)

The Protein Ontology (PRO) web resource provides an integrative framework for protein-centric exploration and enables specific and precise annotation of proteins and protein complexes based on PRO. Functionalities include: browsing, searching and retrieving, terms, displaying selected terms in OBO or OWL format, and supporting URIs. In addition, the PRO website offers multiple ways for the user to request, submit, or modify terms and/or annotation. We will demonstrate the use of these tools for protein research and annotation.

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

William Blake and film noir apparently had the same problem with the urban landscape. While Blake attempts to create a mental world within language that would give a new face of religion to offer comfort to the inhabitants of London, film noir in Los Angeles finds noise and nihilism in the absence of faith. Both struggle with Immanuel Kant, who claimed that reason actively makes the world worthwhile. Hickey and Boggs, a relatively obscure neo-noir movie from 1972, represents (...) the meaninglessness and noise of language, bereft of the religion of Blake and the reason of Kant. (shrink)

A discussion of influential New York Jewish intellectuals, including: Lionel Trilling, Alfred Kazin, Irving Howe, Leslie Fiedler, Daniel Bell, Harold Rosenberg, Saul Bellow, Irving Kristol, and Norman Podhoretz.

Resenha do livro de Sellars, Roy, e Allen, Graham (Orgs.). The Salt Companion to Harold Bloom . Cambridge: Salt, 2007. 505 páginas.

In lieu of an abstract, here is a brief excerpt of the content:Oxymorons of AnxietyOr the Influence of Baba Ram Dass on Harold BloomRichard Klein (bio)A REVIEW OF Harold Bloom. The Anxiety of Influence (New York: Oxford University Press, 1973).In 1974, when I initially submitted this article to diacritics, it was rejected, despite my being a member of the editorial board. I had previously agreed that the piece should first be sent to Harold Bloom for (...) his reaction; he was not pleased. The editor (and founder of diacritics) judged, I think correctly, that it was better to have Bloom well disposed toward the young journal than not. He had been very generous, since its inception, giving us articles and interviews, and lending his weight to this early attempt to translate French theory into America. I was naturally deflated by the rejection, but since I believe in institutions more than individuals, I acquiesced, gracefully I think. Perhaps I shouldn't have. It has been forty years and in that time Bloom has grown even more dismissive of major theoretical developments and contemptuous of efforts to expand the canon. In his latest work, his "virtual swan song," The Anatomy of Influence: Literature as a Way of Life (2011), he evokes the critical developments long championed by this journal, which have evolved over forty years, and lumps them together as: "what I shall call the New Cynicism (a cluster of critical tendencies which are rooted in French theories of culture and encompass the New Historicism and its ilk)."1 Note the ilk: making alike, in a single cluster of cynicism, what he will not differentiate. Currently, he is motivated to return to his earlier work on influence, "galvanized in part by the New Cynicism's reductio of all literary relationships to base self-interest."2 In The Anatomy of Influence, Bloom returns to the Bloom of The Anxiety of Influence to find and redefine a canonical interpretation of literary relationships that depends from his immense erudition. Against the cynics, he is excited by a nobler, disinterested perspective—a view more universally shared than what might be found, for example, in the pages of diacritics.In any case, I always hoped this article, excerpted from a much longer chapter, would one day be published. I didn't think the moment would wait forty years and for my retirement. For allowing this to see the light and for their kind indulgence of my valedictory vanity, I especially want to thank my colleagues deeply, as well as the editors of the new diacritics.Harold Bloom brings bad news. Geoffrey Hartman calls him a kakangelist; he calls himself a necromancer.3 The news is the death of poetry—an event, as Bloom at moments seems to believe, that began with Milton. Since then, things have only gotten worse and are no way bound to improve. What Bloom is saying may well be no news at all, if poetry in fact and in principle has always been dying, if its death were simultaneous with its birth—its possibility permanently implicated in its impossibility. But, if not what the man is saying, surely the way he kakangelizes, raises the most surprising questions about the possibility of something he continues to want to call "literary criticism." Hartman's carefully poised review neglects to insist on the question of Bloom's style. His opening sentence, however, does proceed straight to enumerate—with no further comment—the unwonted diversity of elements that compose Bloom's short theory of poetry: "Six essays emerge from this dense, eloquent and experiential brooding, flanked by two prose poems, and accompanied by a synoptic introduction and an interchapter on 'Antithetical Criticism.'"4 Hartman pretends to take all this perfectly for granted, as if we were quite prepared to understand, with no explanation, the nature and necessity of something called a synoptic introduction, or the status of an interchapter, or the force of a notion like [End Page 7] antithetical criticism, and, as if we should hardly be surprised to discover, the whole thing quite naturally flanked by two prose poems! Hartman picks up the new style, but for reasons not clearly readable in his text, chooses not to dwell on this most surprising news of... (shrink)